The students’ motivation in physical culture

Motives may have different needs, interests, aspirations, desires, attitudes, ideals. From a psychological point of view, the motivation is the main point, compelling a person to engage in physical activity, she gives lessons subjective, personal meaningМотивами могут быть различные потребности, интересы, стремления, желания, установки, идеалы. С психологической точки зрения мотивация является главным моментом, побуждающим человека заниматься физической культурой, она придает занятиям субъективный, личностный смыс

Prediction the biological activity of substances from medicinal plant raw materials by the In silico method with evaluation of extraction efficiency of various types of extractions

Основним принципом фармакокорекції неврозів є призначення седативних, анксіолітичних засобів, з яких краще застосування препаратів рослинного походження, оскільки вони мають меншу кількість побічних ефектів. За допомогою програмного забезпечення PASS здійснено прогнозування протисудомної активності окремих сполук, що входять до складу ЛРС. Виявлено високі індекси протисудомної активності для алкалоїду протопіну, флавоноїду рутину, фумарової кислоти переважно за рахунок взаємодії з ГАМК рецепторами. Розробка технології отримання екстракту методом водної екстракції є цікавим вирішенням питання раціоналізації процесу екстракції.The main principle of pharmacocorrection of neuroses is the prescription of sedatives, anxiolytics, of which the best use of herbal medicines, because they have fewer side effects. Using the PASS software, the prediction of the anticonvulsant activity of individual compounds that include the MPM was carried out. High indices of anticonvulsant activity were found for protopine alkaloid, rutin flavonoid, fumaric acid, mainly due to interaction with GABA receptors. The development of a technology for obtaining the extract by the method of aqueous extraction is an interesting solution to the problem of streamlining the extraction process

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

ВЛИЯНИЕ ВНЕШНЕГО МАГНИТНОГО ПОЛЯ НА СИСТЕМУ АНИЗОТРОПНЫХ НАНОЧАСТИЦ

Our work is a complex investigation of the system of magnetic ellipsoidal nanoparticles based on different theoretical approaches and computer experiments. We study the influence of magnetic field on the self-assembly in the systems of magnetic ellipsoids with various orientation of dipoles

Model of investment-innovative development of economy of depression areas of the region

The sources of financing investment and innovation activities are considered. Based on the analysis, a non&traditional source of investment in innovation is proposed – financial leasing. The objective need for the transition to the region’s economic growth and in the strategic plan for the phased transfer of economic systems to an innovative type of development based on a significant increase in investment activity in a market economy is shown, which is possible through a new scientific understanding of the economic nature of investments and the formation of an effective mechanism for their effective use in technological updating industrial sphere of depressed areas of the region

Technological features of extraction of essential oils from the leaves of Ocimum basilicum, development of dosage form and study of its anticonvulsant activity

Neuropsychiatric diseases, neuroses – occupy a leading place in the list of common diseases of mankind. Stress, illness, poor diet and unhealthy lifestyles are all the foundations of such diseases. The above determines the relevance of the development and introduction to the market of new drugs aimed at pharmacotherapy and pharmacocorrection of these conditions. The main principle of pharmacocorrection of neuroses is the appointment of sedatives, anxiolytics, of which the best use of herbal medicines, because they have fewer side effects. According to the world health organization (WHO), epilepsy is one of the most common central nervous system (CNS) diseases. Epilepsy is treated with several methods, the main of which is the use of antiepileptic drugs with specific mechanisms of action. One of the promising areas of development of drugs for the treatment of epilepsy is the use of phytotherapeutic agents, which has become the task of our work. It is known that herbal medicines can affect various links in the pathogenesis, have a beneficial effect on the CNS as a whole, which significantly reduces the risk of so-called epileptic personality disorders. The purpose of the study is development of technology for obtaining an essential oil extract from O. basilicum, prediction of „drug-like” activity by in silico methods

Directions and prospects of drug development in the context of studying the discipline «Development of drugs»

The discipline «Development of drugs» is a theoretical and practical basis for a set of knowledge and skills that shape future professionals in the field of pharmacy, industrial pharmacy, and is a theoretical basis for a set of knowledge and skills that shape the profile of a specialist in science. The subject of study of the discipline «Development of drugs» are: the basic concepts of development schemes of modern drugs, modern biotechnological methods in the process of drug development, ways and methods to improve the use of natural resources to create new drugs and ensure quality of life and safety. It is known that such studies should be conducted during the life cycle of the product in order to create a quality drug, its registration and quality assurance in mass production. Quality cannot be tested in drugs - quality must be laid down during development. The purpose of pharmaceutical development is to develop a quality drug and its production process in order to constantly produce products with specified functional characteristics. Aim - conducting an overview of literary data on complex experimental studies aimed at scientific substantiation of the composition of the medicinal product in this medicinal form, production process and its control, selection of packaging materials, as well as the study of physicochemical, biological and microbiological properties, which are the main tasks of pharmaceutical development

Prediction of the anticonvulsant activity of ocimum basilicum leaf essential oil using in silico method

The paper examines the analysis of the structure of essential oil of Ocimum basilicum using PASS-forecast. The interest in the study and introduction of herbal medicines into medical practice is not accidental. It is known that herbal medicines can affect various links in the pathogenesis, have a beneficial effect on the CNS as a whole, which significantly reduces the risk of so-called epileptic personality disorders. The paper considers the spectrum of biological activities aimed at studying the anticonvulsant.У роботі розглядається аналіз структури ефірної олії Ocimum basilicum за допомогою PASS-прогнозу. Інтерес до вивчення та впровадження в медичну практику фітопрепаратів не випадковий. Відомо, що фітопрепарати можуть впливати на різні ланки патогенезу, сприятливо впливати на ЦНС в цілому, що значно знижує ризик виникнення так званих епілептичних розладів особистості. У роботі розглянуто спектр біологічної активності, спрямований на вивчення протисудомного потенціалу ефірної олії оцимум базилікум. Метою дослідження є прогнозування біологічної активності речовин Ocimum basilicum L. in silico методом.В работе рассматривается анализ структуры эфирного масла Ocimum basilicum с помощью PASS-прогноза. Интерес к изучению и внедрению в медицинскую практику фитопрепаратов не случаен. Известно, что фитопрепараты могут влиять на разные звенья патогенеза, оказывать благоприятное влияние на ЦНС в целом, что значительно снижает риск возникновения так называемых эпилептических расстройств личности. В работе рассмотрен спектр биологической активности, направленный на изучение противосудорожного потенциала эфирного масла оцимума базиликума